Abstract

The literature indicates that Haplophyllum perforatum Skimmianine main alkaloid belongs to sedative or neuroleptic remedies. The psycho-activating elements have been identified at low doses (1/100 LD50) in the form of: motor and exploratory activity increasing on Lapin and Hall test; extended duration of white mice swimming before the immobilization on Porsolt test; Skimmianine synergy to Benzedrine activating effect; in the test on antagonism to the kataleptogenic effect of haloperidol, anxyolitic effect according to the Kilfoil method. The Skimmianine low doses pharmacological features identified permit to classify it as thymostenic or antidepressant. The peculiarity of Skimmianine is its central M-cholinopositive potentiation caused by arecholin, distinguishing it from traditional antidepressants.