Biomedical and Biological Engineering | Article | Published 2020

Improving the Methods of Molecular Genetic Analysis in Sports by Studying the Gen ACTN3

Collection: International Journal of Virology and Molecular Biology
Keywords: Sport biochemistry, Gene, ACTN3, Polymorphism, Allele endurance, DNA

Abstract

It is known that the physiological characteristics of a person, such as his structure, strength, speed, endurance and characteristics of the nervous system, are inherited individually and are determined genetically. The main advantage of molecular genetic methods is that a person’s behavioral activity is shown to be hereditary, and early diagnosis reveals a highly informative assessment of the possibility of physical development. A distinctive feature of this diagnosis is the ability to identify hereditary trends, the development of factors of occupational diseases, determining the physical performance of a person and reducing the quality of his life.

References

  1. [1] Ahmetov I.I. Genes, athlete status and training – An overview
  2. / I.I. Ahmetov, V.A. Rogozkin // In: Genetics and Sports, ed.:
  3. Collins M. – Medicine and Sport Science.Basel, Karger, V.54.
  4. 2009 -P.43–71.
  5. [2] I.I. Ahmetov, A.M. Druzhevskaya, I.V. Astratenkova, D.V.
  6. Popov, O.L. Vinogradova, V.A. Rogozkin. The ACTN3
  7. R577X polymorphism in Russian endurance athletes // British
  8. Journal of Sports Medicine. V.44. 2010 -P.649–652.
  9. [3] Sharp A.J., Locke D.P., McGrath S.D., et al. Segmental
  10. duplications and copy-number variation in the human genome
  11. //Am J.Hum Genet, vol. 77. 2005 -P.78—88.
  12. [4] Wolfarth В.. Bray M.S., Hagberg J.M., et al. The human gene
  13. map for performance and health-related fitness phenotypes:
  14. the 2004 update // Med. Sci. Sports Ex. vol. 37, №6. 2005 -P.
  15. 881-903.
  16. [5] Nazarov I.В., Woods D.R., Montgomery H.E., et al. The
  17. angiotensin converting enzyme I/D polymorphism in Russian
  18. athletes // Eur. J. Hum. Genet, vol. 9. 2001 -P. 797-801.
  19. [6] Woods D., Hickman M., Jamshidi Y., et al. Elite swimmers
  20. and the D allele of the ACE I/D polymorphism // Hum. Genet,
  21. vol. 108. 2011 -P. 230-232.
  22. [7] Yang N., MacArthur D.G., Gulbm J.P., et al ACTN3
  23. genotype is associated with human elite athletic performance
  24. // Am. J. Hum. Genet, vol. 73, № 3. 2013- P. 627-631.
  25. [8] Rubio J.C., Martin M.A., Rabadan M.. et al. Frequency of the
  26. C34T mutation of the AMPD1 gene in world-class endurance
  27. athletes: does this mutation impairperformance? // J. Appl.
  28. Physiol. vol. 98, № 6. 2005- P. 2108-2112.
  29. [9] Mills M.A., Nan Yang, Weinberger R.P. Differential
  30. expression of the actinbindind proteins, a-actinin-2 and-3, in
  31. different species: implications for the evolution of functional
  32. redundancy // Human Molecular Genetics, vol. 10. № 13.
  33. 2011- P. 1335-1346.
  34. [10] Montgomery H., Clarkson P., Bornard M. et al.
  35. Angiothensin-converting enzyme gene insertion/deletion
  36. polymorphism and response to physical training // Lancet, vol.
  37. 53. 2009-P. 541-545.
  38. [11] Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ,
  39. Argyropoulos G, Walts B, Pérusse L, Bouchard C // Genes
  40. and Endurance Performance. 25 NOV 2010-P. 54-59.
  41. [12] Weyand P.G., Davis A.J, Running performance has a
  42. structural basis // The Journal of Experimental Biology, 2005-
  43. vol. 208- P. 2625-2631.
  44. [13] Chen S, Yan W., Huang J, et al. Peroxisome
  45. proliferator-activated receptor-gamma coactivator-1 alpha
  46. polymorphism is not associated with essential hypertension
  47. and type 2 diabetes mellitus in Chinese population //
  48. Hypertens Res, 2004 -vol. 27, №11. P. 813-820.
  49. [14] Lucia A., Gomez-Gallego R, Barroso I., et al. PPARGCI
  50. Agenotype (Gly482Ser) predicts exceptional endurance
  51. capacity in European men. // J. Appl. Physiol, 2005 - vol.99,
  52. №1. P. 344-348.
  53. [15] Braissant O.. Foufelle R, Scotto C, et al. Differential
  54. expression of peroxisome proliferator-activated receptors
  55. (PPARs): tissue distribution of PPAR-alpha, — beta, and —
  56. gamma in the adult rat // Endocrinology, 2006- vol. 137.
  57. P.354—366.
  58. [16] Morisaki T, Gross M, Morisaki H, Pongratz D, Zöllner N,
  59. Holmes EW. Molecular basis of AMP deaminase deficiency
  60. in skeletal muscle //Proc Natl Acad Sci U S A. Jul 14. 2012- P.
  61. 6457-6461.
  62. [17] Juan C. Rubio, Miguel A. Martґın, Manuel Rabadaґn, Fґelix
  63. Gґomez-Gallego, Alejandro F. San Juan. Frequency of the
  64. C34T mutation of the AMPD1 gene in world-class endurance
  65. athletes: does this mutation impair performance? // J Appl
  66. Physiol 98: 2015- P. 2108–2112.
  67. [18] Philip F. Binkley, Alex Auseon, Glen Cooke. A
  68. Polymorphism of the Gene Encoding ACTN3:
  69. ClinicalImpact and Proposed Mechanisms in Congestive
  70. Heart Failure //Congestive Heart Failure. September 21, 2014
  71. - P. 274–280.
Loading...
0

Views

0

Reads

0

Comments

0

Reviews

0

Liked

0

Shared

0

Bibliography

0

Citations

Like and share on

Cite this publication

Copy text below and use in your article